SML2070

Sigma-Aldrich

23-Hydroxybetulinic acid

≥98% (HPLC)

Sinónimos:
Anemosapogenin, (3β,4α)-3,23-Dihydroxylup-20(29)-en-28-oic acid, 3aH-Cyclopentaachrysene, lup-20(29)-en-28-oic acid deriv., 3β,23-Dihydroxylup-20(29)-en-28-oic acid
Empirical Formula (Hill Notation):
C30H48O4
Número de CAS:
Peso molecular:
472.70
MDL number:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

powder

storage condition

under inert gas

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

OC@H1CCC@@2(C)C@(CCC@3(C)C@2(H)CCC@@4(H)C@@3(C)CCC@5(C(O)=O)C@4(H)C@H(C(C)=C)CC5)(H)C@1(C)CO

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Biochem/physiol Actions

23-Hydroxybetulinic acid is a cytotoxic agent from rizoma of Pulsatilla chinensis (Bunge) Regel. Anticancer activity of 23-Hydroxybetulinic acid is associated with depolarizations of the mitochondrial membrane potential and subsequent cell apoptosis. Additionally it induces autophagic cell death in HL-60 cells via the up regulation of Beclin-1.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Yi Bi et al.
Molecules (Basel, Switzerland), 17(8), 8832-8841 (2012-07-27)
23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i...
Nan Yao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(3), 838-852 (2015-09-19)
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, only sorafenib is approved to treat HCC. In this study, we found that a 23-hydroxybetulinic acid derivative, B4G2, exhibited potent antiproliferative activity in HCC cell lines. We...
Ming Liu et al.
Pharmaceutical biology, 53(1), 1-9 (2014-07-16)
The rizoma of Pulsatilla chinensis (Bunge) Regel has been used as a traditional Chinese medicinal herb for thousands of years. Total saponins from P. chinensis can induce the apoptosis of solid cancer cells; however, their activity on chronic myeloid leukemia...

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