Merck
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SML2152

Sigma-Aldrich

10Panx1 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):
WRQAAFVDSY trifluoroacetate salt, 10Panx trifluoroacetate salt, Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr trifluoroacetate salt
Empirical Formula (Hill Notation):
C58H79N15O16 · xC2HF3O2
CAS Number:
Molecular Weight:
1242.34 (free base basis)
NACRES:
NA.77

ensayo

≥98% (HPLC)

formulario

film

color

white to beige

enviado en

wet ice

temp. de almacenamiento

−20°C

Aplicación

10Panx1 trifluoroacetate salt has been used as the selective pannexin-1 mimetic inhibitory peptide to study the involvement of pannexin-1 in praliciguat (PRL) inhibition of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome.

Acciones bioquímicas o fisiológicas

The pannexin-1 (panx1) extracellular sequence-derived 10panx1 functions as a reversible panx1 channel blocker (IC50 = 52 μM; human panx1-overexpressing HEK cells) that effectively inhibits ATP-induced dye-uptake in panx1 HEK cells co-expressing rat or human P2X7R (IC50 = 93 μM), as well as in murine J774 and human alveolar macrophages (Effective conc. 100-200 μM). 10panx1 (100 μM) is shown to protect rat hippocampal neurons against death induction upon NMDAR overactivation by excitotoxic concentrations of NMDA (100 μM) in cultures and ameliorate withdrawal symptoms among morphine-treated rats in vivo (10 μg/rat via intrathecal injection).

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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