Todas las fotos(1)

SML2160

Sigma-Aldrich

R-568 hydrochloride

≥95% (HPLC)

Sinónimos:
Tecalcet hydrochloride, NPS-R 568 hydrochloride, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride (1:1), R 568 hydrochloride, KRN 568 hydrochloride, Norcalcin hydrochloride
Empirical Formula (Hill Notation):
C18H22ClNO · HCl
Número de CAS:
Peso molecular:
340.29
Número MDL:

ensayo

≥95% (HPLC)

formulario

powder

actividad óptica

[α]/D +35 to +40°, c = 0.5 in chloroform-d

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

DMSO: 2 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

SMILES string

C[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl

InChI

1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1

InChI key

YJXUXANREVNZLH-PFEQFJNWSA-N

Acciones bioquímicas o fisiológicas

R-568 is a positive allosteric modulator of the calcium-sensing receptor (CaSR), increasing the sensitivity to activation by extracellular Ca2+. In rats, orally administered R-568 decreases plasma levels of PTH and Ca2+ and, at higher doses, increases plasma levels of calcitonin.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Jenny Ying Lin Lu et al.
The Journal of pharmacology and experimental therapeutics, 331(3), 775-786 (2009-09-18)
Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial hypocalciuric hypercalcemia (FHH), whereas homozygous inactivating mutations can cause life-threatening neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the hCaSR can
Fanny Bery et al.
Cancers, 12(4) (2020-04-08)
The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR
Asuka Masumoto et al.
Journal of atherosclerosis and thrombosis, 24(7), 716-724 (2016-11-15)
Vascular calcification (VC) is a risk factor of cardiovascular and all-cause mortality in patients with chronic kidney disease (CKD). CKD-mineral and bone metabolism disorder is an important problem in patients with renal failure. Abnormal levels of serum phosphate and calcium
Abhishek Aggarwal et al.
Biochimica et biophysica acta, 1853(9), 2158-2167 (2015-02-24)
The inverse correlation between dietary calcium intake and the risk of colorectal cancer (CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that

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