SML2161

Sigma-Aldrich

STA-21

≥95% (HPLC)

Sinónimos:
(±)-Deoxytetrangomycin, (±)-Ochromycinone, STA21, 3,4-Dihydro-8-hydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione, STA 21, NSC 628869
Empirical Formula (Hill Notation):
C19H14O4
Número de CAS:
Peso molecular:
306.31
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥95% (HPLC)

form

powder

color

yellow to brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC1CC(C(C(C(C(C=CC=C2O)=C2C3=O)=O)=C3C=C4)=C4C1)=O

Biochem/physiol Actions

STA-21 is a STAT3 inhibitor that reduces the constitutively high STAT3 transcriptional activity in Caov-3 and MDA-MB-435s cultures (by 9.125- and 5.765-fold, respectively, post 48-hr 20 μM treatment) by disrupting STAT3 homodimerization, an essential process for STAT3 nuclear localization and DNA-binding activity. STA-21 selectively inhibits the growth and survival of breast carcinoma cells with constitutive Stat3 signaling (26%, 25%, 56% apoptotic cells, respectively, in MDA-MB-231, MDA-MB-435s, and MDA-MB-468 cultures, respectively, post 48-hr 20 μM treatment) but not those without (<10% apoptosis in MCF7, MDA-MB-453, HSF cultures post 48-hr 20 μM treatmen). STA-21 is reported to alleviate autoimmune inflammation in a murine model of rheumatoid arthritis (RA; 0.5 mg/kg; 3X i.p./week) and reduce airway inflammation in allergic mice with psoriatic inflammation (20 μg/mouse/day topically) in vivo.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Chun-Liang Chen et al.
Molecular cancer, 7, 78-78 (2008-10-23)
Constitutive activation of signal transducer and activator of transcription 3 (Stat3) signaling pathway plays an important role in several human cancers. Activation of Stat3 is dependent on the phosphorylation at the tyrosine residue 705 by upstream kinases and subsequent nuclear...
Chun-Liang Chen et al.
BMC cancer, 7, 111-111 (2007-06-30)
Stat3 has been classified as a proto-oncogene and constitutive Stat3 signaling appears to be involved in oncogenesis of human cancers. However, whether constitutive Stat3 signaling plays a role in the survival and growth of osteosarcomas, rhabdomyosarcomas, and soft-tissue sarcomas is...
Sheikh Fayaz Ahmad et al.
Immunobiology, 222(2), 206-217 (2016-10-09)
We set out to investigate the influence of STA-21, a dynamic STAT-3 inhibitor, on the expansion and progression of rheumatoid arthritis (RA), and to determine its potential mechanisms of action in a mouse model of collagen antibody-induced arthritis (CAIA). To...
Macarena Garrido-Tapia et al.
Immunobiology, 222(11), 1043-1051 (2017-06-06)
NKG2D is an activating receptor expressed on NK cells that binds to a variety of ligands, including MICA and MICB. These cell surface glycoproteins are overexpressed under cellular transformation, thus playing an important role in cell-mediated immune response to tumors....
Davide Genini et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(25), E4924-E4933 (2017-06-07)
In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high affinity to the...

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