SML2182

Sigma-Aldrich

Succinobucol

≥98% (HPLC)

Sinónimos:
Butanedioic acid 1-4-1-3,5-bis(1,1-dimethylethyl)-4-hydroxyphenylthio-1-methylethylthio-2,6-bis(1,1-dimethylethyl)phenylester, Probucol monosuccinate, AGI-1067
Empirical Formula (Hill Notation):
C35H52O5S2
Peso molecular:
616.91
MDL number:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(C(C)(C)C)C=C(SC(C)(C)SC2=CC(C(C)(C)C)=C(OC(CCC(O)=O)=O)C(C(C)(C)C)=C2)C=C1C(C)(C)C

Biochem/physiol Actions

Succinobucol is a metabolically stable derivative of the antioxidant drug probucol that poses a distinct pharmacological from. Succinobucol is an orally active vascular protectant that exhibits antiatherosclerotic properties in multiple animal models and in humans. It inhibits the release of proinflammatory cytokines, TNF-a, IL-1b, and IL-6 in hPBMC activated by LPS.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Stephanie A Houston et al.
Platelets, 28(3), 295-300 (2016-09-30)
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. Given the importance of oxidant stress in modulating platelet-platelet and platelet-vessel wall interactions, the aim of this study was to establish if antioxidant activity was responsible for the antiplatelet activity...
Charles Kunsch et al.
The Journal of pharmacology and experimental therapeutics, 308(3), 820-829 (2003-11-18)
Atherosclerosis is a disease of oxidative stress and inflammation. AGI-1067 [butanedioic acid, mono[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-,hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis (1,1-dimethylethyl)phenyl] ester] is a metabolically stable derivative of, yet pharmacologically distinct from, the antioxidant drug probucol. It is a member of a novel class of orally active...
Dirleise Colle et al.
Molecular neurobiology, 53(2), 1280-1295 (2015-01-27)
Succinobucol (succinyl ester of probucol) is a lipid-lowering compound with anti-inflammatory and antioxidant properties. Recent experimental evidence has highlighted the potential neuroprotective effects of succinobucol. In the present study, cultured neuroblastoma (SH-SY5Y) cells were used to investigate mechanisms mediating the...

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