SML2193

Sigma-Aldrich

Altenusin

≥98% (HPLC)

Sinónimos:
3,4′,5′-Trihydroxy-5-methoxy-2′-methyl[1,1′-biphenyl]-2-carboxylic acid, Alutenusin
Empirical Formula (Hill Notation):
C15H14O6
Número de CAS:
Peso molecular:
290.27
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

Penicillium sp.

assay

≥98% (HPLC)

form

powder

color

yellow to orange

storage temp.

−20°C

SMILES string

OC1=CC(C2=CC(OC)=CC(O)=C2C(O)=O)=C(C)C=C1O

InChI

1S/C15H14O6/c1-8-5-13(16)14(17)7-11(8)12-6-9(20-2)3-4-10(12)15(18)21-19/h3-7,16-17,19H,1-2H3

InChI key

GWGIZSANXIQQQR-UHFFFAOYSA-N

Biochem/physiol Actions

Altenusin, a non-steroidal fungal metabolite, is a potent and selective agonist of Farnesoid X receptor (FXR) that protects mice from high-fat diet induced obesity. Also it decreases blood glucose level, serum insulin level, and reduces lipid droplets accumulation. Altenusin inhibits trypanothione reductase from Trypanosoma cruzi.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Betania Barros Cota et al.
FEMS microbiology letters, 285(2), 177-182 (2008-06-19)
Parasitic protozoan species belonging to the genera Trypanosoma and Leishmania are the etiological agents of several diseases in tropical areas of the world, for which there is an urgent need for effective and affordable treatment. In this regard, we are...
Sook Wern Chua et al.
ACS chemical neuroscience, 8(4), 743-751 (2017-01-10)
In Alzheimer's disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (NFTs). A critical step in the formation of NFTs is the conversion of soluble tau into insoluble filaments. Accordingly, a current therapeutic strategy in clinical trials is aimed at...
Zhihui Zheng et al.
Molecular pharmacology, 92(4), 425-436 (2017-07-26)
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The incidence of NAFLD has increased steadily due to its close association with the global epidemic of obesity and type 2 diabetes. However, there is no effective pharmacological therapy...

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