Merck
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SML2464

Sigma-Aldrich

KRN2

≥98% (HPLC)

Synonym(s):
13-[(2-Fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride, KRN2
Empirical Formula (Hill Notation):
C27H23FClNO4
CAS Number:
Molecular Weight:
479.93
Número MDL:

ensayo

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

faint yellow to dark orange

solubilidad

H2O: 2 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

SMILES string

FC(C=CC=C1)=C1CC2=C([N+](CC3)=CC4=C2C=CC(OC)=C4OC)C5=C3C=C(OCO6)C6=C5.[Cl-]

Acciones bioquímicas o fisiológicas

KRN2 is a specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes. KRN2 suppresses migration of Fibroblast-like synoviocytes stimulated with TGF-β. KRN2 ameliorates experimental arthritis in mice.
KRN2 or 13-(2-fluorobenzyl)-berberine is a berberine derivative that effectively blocks the invasiveness of fibroblast-like synoviocytes (FLS). It is stable and orally bioavailable. It suppresses the production of proinflammatory cytokines to ameliorate arthritis severity.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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