SML2591

Sigma-Aldrich

SCH-39166 hydrobromide

≥98% (HPLC)

Sinónimos:
(6aS,13bR)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzodnaphth2,1-bazepin-12-ol hydrobromide, (6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-Benzodnaphth2,1-bazepin-12-ol hydrobromide, PSYRX 101 hydrobromide, (-)-trans-6,7,7a,8,9,13b-Hexahydro-3-chloro-2-hydroxy-N-methyl- 5H-benzodnaptho-(2,1-b)azepine hydrobromide, PSYRX-101 hydrobromide, PSYRX101 hydrobromide, SCH 39166 hydrobromide, Ecopipam hydrobromide, SCH39166 hydrobromide
Empirical Formula (Hill Notation):
C19H20ClNO·HBr
Peso molecular:
394.73
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

SCH-39166 (ecopipam) is a high-affinity D1/D5 subtype-selective dopamine receptor antagonist (Ki = 1.2 nM/D1, 2.0 nM/D5, 980 nM/D2, 5.52 μM/D4, 80 nM/5-HT, 731 nM/α2a). SCH-39166 is widely employed both in cultures and in animal studies in vivo.

pictograms

Exclamation mark

signalword

Warning

hcodes

Target Organs

Central nervous system

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Furong Huang et al.
Investigative ophthalmology & visual science, 59(6), 2623-2634 (2018-05-31)
To determine the roles of dopamine D2 receptors (D2Rs) and dopamine D1 receptors (D1Rs) in the inhibition of form-deprivation myopia (FDM) by the nonselective dopamine agonist apomorphine (APO) in D2R-knockout (D2R-KO) and D1R-KO mice. Retinal layer thicknesses and electroretinograms (ERGs)...
Fabian Philippart et al.
eLife, 7 (2018-12-18)
Dopamine (D2) receptors provide autoinhibitory feedback onto dopamine neurons through well-known interactions with voltage-gated calcium channels and G protein-coupled inwardly-rectifying potassium (GIRK) channels. Here, we reveal a third major effector involved in D2R modulation of dopaminergic neurons - the sodium...
Stephanie Roughley et al.
Psychopharmacology, 236(6), 1853-1862 (2019-01-27)
Previous work has identified that different forms of Pavlovian conditioned approach, sign-tracking and goal-tracking, are governed by distinct neurochemical mechanisms when compared in animals predisposed to learning one form vs. the other. The present study aimed to investigate whether these...
Nao Matsuyama et al.
Respiratory research, 19(1), 53-53 (2018-04-03)
Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gicoupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway smooth muscle and regulate airway smooth muscle force. However, functional...
Brendan D Hare et al.
Nature communications, 10(1), 223-223 (2019-01-16)
Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear...

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