SML2620

Sigma-Aldrich

Bromonoscapine

≥98% (HPLC)

Sinónimos:
(S)-3-((R)-9-bromo-4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3dioxolo4,5-gisoquinolin-5-yl)-6,7-dimethoxyisobenzofuran-1(3H)-one, 9-Bromonoscapine, EM 011
Empirical Formula (Hill Notation):
C22H22BrNO7
Número de CAS:
Peso molecular:
492.32
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

powder

optical activity

α/D -100 to -120°, c = 1 in dichloromethane

color

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Bromonoscapine is a microtubular disrupting agent that exhibits potent cytotoxic activity against breast, lung and other cancers.

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Jun Zhou et al.
Molecular pharmacology, 63(4), 799-807 (2003-03-20)
Noscapine, a microtubule-interfering agent, has been shown to arrest mitosis, to induce apoptosis, and to have potent antitumor activity. We report herein that two brominated derivatives of noscapine, 5-bromonoscapine (5-Br-nosc) and reduced 5-bromonoscapine (Rd 5-Br-nosc), have higher tubulin binding activity...
Akhilesh Kumar Verma et al.
Bioorganic & medicinal chemistry, 14(19), 6733-6736 (2006-06-21)
Three haloderivatives of noscapine 2-4 were synthesized chemoselectively and their in vitro cytotoxicity was assessed by MTT assay on U-87 human glioblastoma cell lines. At 50 microM concentration after 72 h, 9-chloronoscapine 2, 9-bromonoscapine 3 (EM011), and 9-iodonoscapine 4 killed...
Maged Henary et al.
Biochemical pharmacology, 92(2), 192-205 (2014-08-16)
Noscapine, an opium-derived 'kinder-gentler' microtubule-modulating drug is in Phase I/II clinical trials for cancer chemotherapy. However, its limited water solubility encumbers its development into an oral anticancer drug with clinical promise. Here we report the synthesis of 9 third-generation, water-soluble...

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico

Redes sociales

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Investigación. Desarrollo. Producción.

Somos un proveedor líder para la industria de Ciencias de la Vida con soluciones y servicios para investigación, desarrollo y producción biotecnológicos, y para desarrollo y producción de tratamientos farmacéuticos

© 2021 Merck KGaA, Darmstadt, Alemania y/o sus filiales. Todos los derechos reservados.

Queda estrictamente prohibida la reproducción sin permiso de cualquiera de los materiales de la página web.