Merck
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SML2738

Sigma-Aldrich

SM1-71

≥98% (HPLC)

Synonym(s):
N-[2-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide
Empirical Formula (Hill Notation):
C24H26ClN7O
CAS Number:
Molecular Weight:
463.96

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

2-8°C

Acciones bioquímicas o fisiológicas

SM1-71 is a cell penetrant and potent multi-targeted kinase inhibitor that engages kinases through both reversible and irreversible binding. SM1-71 covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK(MLTK), MAP3K1, LIMK1, and RSK2. It binds to the cysteine located in vicinity of active site. In some cases, SM1-71 might bind to Cys located at allosteric places. SM1-71 potently inhibits growth of multiple cancer cell lines.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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