SML2774

Sigma-Aldrich

KDOAM25 hydrochloride hydrate

≥98% (HPLC)

Sinónimos:
KDOAM-25 hydrochloride hydrate, 2-2-2-(Dimethylamino)ethyl-ethylamino-2-oxoethylaminomethylpyridine-4-carboxamide hydrochloride hydrate, 2-2-2-(Dimethylamino)ethyl-ethyl-amino-2-oxidanylidene-ethylaminomethylpyridine-4-carboxamide hydrochloride hydrate
Empirical Formula (Hill Notation):
C15H25N5O2 · xHCl · yH2O
Peso molecular:
307.39 (anhydrous free base basis)
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Monica M Montano et al.
Breast cancer research : BCR, 21(1), 138-138 (2019-12-07)
The tumor suppressor actions of hexamethylene bis-acetamide (HMBA)-inducible protein 1 (HEXIM1) in the breast, prostate, melanomas, and AML have been reported by our group and others. Increased HEXIM1 expression caused differentiation and inhibited proliferation and metastasis of cancer cells. Historically...
Anthony Tumber et al.
Cell chemical biology, 24(3), 371-380 (2017-03-07)
Methylation of lysine residues on histone tail is a dynamic epigenetic modification that plays a key role in chromatin structure and gene regulation. Members of the KDM5 (also known as JARID1) sub-family are 2-oxoglutarate (2-OG) and Fe2+-dependent oxygenases acting as...
Simone Pippa et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-08)
Background: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different kinds of cancer, including breast, prostate and bladder carcinomas, with positive effects on cancer proliferation and chemoresistance. For these...

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