Merck
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SML2807

Sigma-Aldrich

JP4-039

≥98% (HPLC)

Synonym(s):
4-[[(3E,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-7-methyl-1-oxo-3-octen-1-yl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy, JP 4-039
Empirical Formula (Hill Notation):
C23H42N3O4
CAS Number:
Molecular Weight:
424.60

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

faint yellow to dark orange

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

−20°C

SMILES string

O=C(C/C=C/[C@@H](NC(OC(C)(C)C)=O)CC(C)C)NC1CC(C)(C)N([O])C(C)(C)C1

Acciones bioquímicas o fisiológicas

JP4-039 is an electron-/reactive oxygen species (ROS)-scavenging GS-nitroxide composed of 4-amino-TEMPO and a truncated gramicidin S (GS) mitochrondria-targeting sequence. JP4-039 is a superior irradiation mitigator than XJB-5-131 (33% vs. 20% mice survial rate on day 35 with respective compound; 23.6 μmol/kg iv. 24 hr post 9.5 Gy whole body irradiation), while displaying weaker anti-ferroptotic potency (EC50 = 3.58 μM/1.27 μM against 10 μM erastin-/2 μM RSL3-induced HT-1080 ferroptosis vs. 114 nM/68 nM with XJB-5-131) due to lower lipophilicity & mitochondria enrichment. Typical dosing range: 40 nM-10 μM in cultures and 10-20 mg/kg in mice (im., ip., iv.) in vivo.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

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