SML2861

Sigma-Aldrich

FIT-039

≥98% (HPLC)

Sinónimos:
FIT 039, N-5-Fluoro-2-(1-piperidinyl)phenyl-4-pyridinecarbothioamide, FIT039, N-(5-Fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide
Empirical Formula (Hill Notation):
C17H18FN3S
Número de CAS:
Peso molecular:
315.41
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

FIT-039 is a potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor that binds to the ATP -binding pocket of CDK9 and inhibits the kinase activity of P-TEFb complex. FIT-039 inhibits replication of herpes simplex virus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured cells. FIT-039 ointment inhibits formation of skin legion in a mice HSV-1 infection model.

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Eriko Sumi et al.
Clinical drug investigation, 39(1), 55-61 (2018-10-05)
Cutaneous warts are caused by human papilloma virus (HPV) infection. FIT039, a specific inhibitor of CDK9, suppresses the proliferation of DNA viruses in vitro. We evaluated the safety, plasma concentrations, and efficacy of FIT039 delivered by single application of an...
Makoto Yamamoto et al.
The Journal of clinical investigation, 124(8), 3479-3488 (2014-07-09)
A wide range of antiviral drugs is currently available; however, drug-resistant viruses have begun to emerge and represent a potential public health risk. Here, we explored the use of compounds that inhibit or interfere with the action of essential host...
Masahiko Ajiro et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(18), 4518-4528 (2018-05-02)
Purpose: Cervical cancer is one of the leading causes of cancer-related deaths among women worldwide. The purpose of this study is to assess the therapeutic effect of the newly developed cyclin-dependent kinase 9 (CDK9) inhibitor FIT-039 on cervical neoplasia induced...

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