Merck
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SML2873

Sigma-Aldrich

EIDD-2801

≥98% (HPLC)

Synonym(s):
EIDD2801, EIDD 1931 5′-isopropylester, N4-Hydroxycytidine 5′-isopropylester, beta-D-N4-Hydroxycytidine 5′-isopropylester, EIDD 1931 prodrug, N4OHcyd ester, 4-N-HO-Cyd ester, EIDD1931 prodrug, EIDD-1931 prodrug, N4-OHcyd ester, (oh)4Cyd lester, NHC ester, EIDD-1931 5′-isopropylester, EIDD1931 5′-isopropylester, EIDD 2801, ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate, BHC ester
Empirical Formula (Hill Notation):
C13H19N3O7
CAS Number:
Molecular Weight:
329.31

Nivel de calidad

100

ensayo

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

−20°C

Acciones bioquímicas o fisiológicas

EIDD-2801 is an orally active, 5′-isopropylester prodrug form of the antiviral ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) with known anti-viral activity against SARS-CoV, SARS-CoV-2, RSV, influenza A & B (IAV & IBV), HCV, pestivirus, bovine viral diarrhoea virus (BVDV), Ebola (EBOV), Chikungunya (CHIKV), venezuelan equine encephalitis (VEEV). EIDD-2801 is efficiently hydrolyzed to NHC in vivo, being more orally bioavailable than NHC in nonhuman primates and ferrets, while maintaining similar oral bioavailability as NHC in mice. EIDD-2801 displays in vivo efficacy against pandemic and seasonal IAV strains in ferrets (lowest ED = 2.3 and 7 mg/kg b.i.d. p.o., respectively).

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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Certificate of Origin

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