Merck
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SRP0399

Sigma-Aldrich

Histone H3 peptide (Mono-methylated K9), biotin

≥95% (HPLC)

NACRES:
NA.32

ensayo

≥95% (HPLC)

formulario

aqueous solution

envase

pkg of 500 μL

concentración

40 μM

enviado en

dry ice

temp. de almacenamiento

−70°C

Descripción general

Histone H3 peptide mono-methylated at Lysine 9, biotinylated, substrate for histone demethylases belonging to the Jumanji domain-containing (JMJ) family .

Aplicación

Suitable as a substrate for histone demethylases belonging to the Jumonji (JMJ) family. It can be used to study enzyme kinetics, and to screen small molecular inhibitors of these demethylases for drug discovery and HTS applications.

Otras notas

500 μL at 40 μM, or 20 nmol Sold as 500 μL

Código de clase de almacenamiento

12 - Non Combustible Liquids

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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Certificado de origen

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Shiv I S Grewal et al.
Current opinion in cell biology, 16(3), 230-238 (2004-05-18)
Heterochromatin mediates various nuclear processes including centromere function, gene silencing and nuclear organization. Although it was discovered nearly 75 years ago, the pathways involved in heterochromatin establishment, assembly and epigenetic maintenance have been elusive. Recent reports have demonstrated that distinct
Judd C Rice et al.
Molecular cell, 12(6), 1591-1598 (2003-12-24)
The functional significance of mono-, di-, and trimethylation of lysine residues within histone proteins remains unclear. Antibodies developed to selectively recognize each of these methylated states at histone H3 lysine 9 (H3 Lys9) demonstrated that mono- and dimethylation localized specifically

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