Merck
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SRP2024

Sigma-Aldrich

PC4, serine mutations human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):
MGC102747, P15, p14, PC4
NACRES:
NA.26

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥80% (SDS-PAGE)

formulario

frozen liquid

mol peso

~14.4 kDa

envase

pkg of 10 μg

concentración

1000 μg/mL

color

clear colorless

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... SUB1(10923)

Acciones bioquímicas o fisiológicas

Human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vitro and in vivo. PC4 strongly binds single stranded DNA and the region essential for the single stranded DNA binding activity was mapped around residue 77. A single amino acid change at position 77 (F to P) abolishes both ds- and ss-DNA binding activity.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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