Merck
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SRP2077

Sigma-Aldrich

p53 (1-363) C-terminal deletion human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

Synonym(s):
FLJ92943, LFS1, P53, TRP53
NACRES:
NA.26

origen biológico

human

recombinante

expressed in insect cells

ensayo

≥80% (SDS-PAGE)

formulario

frozen liquid

mol peso

~41.8 kDa

envase

pkg of 5 μg

concentración

850 μg/mL

color

clear colorless

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... TP53(7157)

Acciones bioquímicas o fisiológicas

Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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