Merck
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SRP2096

Sigma-Aldrich

p300-Ch1 (302-531) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):
KAT3B, RP1-85F18.1, RSTS2, p300
NACRES:
NA.26

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥80% (SDS-PAGE)

formulario

frozen liquid

mol peso

~26 kDa

envase

pkg of 10 μg

concentración

1000 μg/mL

color

clear colorless

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... EP300(2033)

Descripción general

The EP300 (E1A binding protein p300) gene is mapped to human chromosome 22q13.2. It codes for a histone acetyltransferase which is ubiquitously expressed.

Acciones bioquímicas o fisiológicas

Human p300 and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with variety of cellular factors and onco-proteins, loss of the wild type CBP alleles in isolated tumors suggests that CBP/p300 might serve as tumor suppressors. The ability of p300 to acetylate many transcription factors, including p53, E2F, TFIIE, and TFIIF etc. demonstrated a novel mechanism of targeted p300 regulation of gene expression.
Loss of EP300 (E1A binding protein p300) gene function causes Rubinstein-Taybi syndrome. p300 is essential for cell differentiation, growth and survival. p300 promotes liver stiffness, which is known to induce hepatic stellate cell differentiation to tumor-promoting myofibroblasts.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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