SRP4029

Eotaxin from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonym(s): Eosinophil chemotactic protein chemokine (C-C motif) ligand 11, CCL11, SCYA11, Small inducible cytokine A11
• Número MDL: MFCD01093488

Properties

• origen biológico: mouse
• recombinante: expressed in E. coli
• ensayo: ≥98% (HPLC); ≥98% (SDS-PAGE)
• formulario: lyophilized
• mol peso: ~8.4 kDa
• envase: pkg of 10 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: endotoxin, tested
• Nº de acceso NCBI: P48298
• Nº de acceso UniProt: P48298
• enviado en: wet ice
• temp. de almacenamiento: −20°C
• Gene Information: mouse ... Ccl11(20292)

Description

Descripción general

Eotaxin is a member of the CC chemokine family, and belongs to the MCP/eotaxin subfamily. It has a wide range of tissue expression, such as thymus, heart, lungs, lymph nodes, kidney, and intestines. It is also expressed by epithelial cells of lung, pleural mesothelial cells, epithelial cells of bronchial airway, and smooth muscle cells (SMCs).

Acciones bioquímicas o fisiológicas

Eotaxin is a chemoattractant for eosinophils, and is involved inflammatory diseases, such as asthma. It is induced by glucocorticoids and cytokines. Along with interleukin-5 (IL-5) it results in airway hyperresponsiveness (AHR), and hence, lung inflammatory disorders. In humans, it leads to respiratory syncytial virus (RSV) vaccine-enhanced disease, and the eosinophils are also responsible for the elimination of virus. It might also be involved in the pathophysiology of inflammatory bowel diseases which involve eosinophils. It can lead to the production of reactive oxygen species, thus, resulting in damaged tissue. It is overexpressed in multiple diseases such as allergic rhinitis, nasal polyposis, endometriosis and Hodgkin′s disease.

Forma física

Sterile filtered and then lyophilized with no additives. The protein may appear as a haze or film that is difficult to see at the bottom of the vial.

Reconstitución

Reconstitute in water to a concentration of 0.1-1 μg/μL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable