SRP4524

BD-3 human

recombinant, expressed in E. coli

• Synonym(s): HBP3, HBD3, DEFB3, HDB-3, DEFB103
• NACRES: NA.32

Properties

• origen biológico: human
• recombinante: expressed in E. coli
• formulario: lyophilized
• mol peso: ~5 kDa
• envase: pkg of 20 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: endotoxin, tested
• Nº de acceso NCBI: P81534
• enviado en: wet ice
• temp. de almacenamiento: −20°C
• Gene Information: human ... DEFB103A(414325)

Description

Descripción general

β-defensin-3 (BD-3) is an anti-microbial peptide produced by airway epithelial cells, lung-derived epithelial cells and keratinocytes. It has a molecular weight of 5kDa. The gene encoding this protein is localized on human chromosome 8p23.1. Recombinant human β-defensin-3 (BD-3) is an antimicrobial peptide, which belongs to the distinct family of β-defenisns. Recombinant human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.

Chemical structure: peptide

Acciones bioquímicas o fisiológicas

β-defensin-3 (BD-3) associates with bacterial products which reduce the effect of inflammatory cytokine responses. The protein has been shown to stimulate the production of interferon-α and activate monocytes through toll-like receptors 1 and 2. It antagonizes the activation of C-X-C motif chemokine receptor 4 (CXCR4).

Forma física

Sterile filtered and lyophilized with no additives.

Reconstitución

Reconstitute in 10 mM Acetic acid to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable