SRP4576

Sigma-Aldrich

BMP-11 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sinónimos:
bone morphogenetic protein 11, BMP 11, Growth/Differentiation Factor-11, GDF11
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

~32.6 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GDF11(10220)

Categorías relacionadas

General description

BMPs (bone morphogenetic proteins) belong to the transforming growth factor-β (TGF-β) superfamily of structurally related signaling proteins. BMP-11 is also known as growth differentiation factor 11 (GDF11). Recombinant human BMP-11 is a N-terminus His-tagged protein with a molecular weight of 32.6kDa (for homodimeric) and 16.2kDa (for monomeric) consisting of 136 amino acid polypeptide chains.

Biochem/physiol Actions

As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. They also enhance protein degradation and reduce skeletal muscle protein synthesis. BMP-11 may have a role in the development of the nervous system in mice. It acts as a modulator of development and differentiation. In mice, circulating levels of BMP-11 decrease with age.

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 3.5.

Reconstitution

Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 μg BSA per 1 μg of protein). This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Certificado de Análisis
GDF11 does not rescue aging-related pathological hypertrophy.
Smith SC
Circulation Research, 117(11), 926-932 (2015)
Clinical significance of growth differentiation factor 11 in colorectal cancer.
Yokoe T
International Journal of Oncology, 31(5), 1097-1101 (2007)
Growth differentiation factor 11 is an encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.
Vanbekbergen N
BMC Research Notes, 7, 766-766 (2014)

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