SRP4589

Sigma-Aldrich

FGF-20 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:
FGFK, Fibroblast growth factor 20, FGF20
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

~24 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF20(26281)

Categorías relacionadas

General description

The gene FGF20 (fibroblast growth factor 20) is mapped to human chromosome 8p22-p21.3. It is strongly expressed in the substantia nigra of the brain. It is also expressed during early embryonic development. FGF20 belongs to the FGF class of genes.

Biochem/physiol Actions

FGF20 (fibroblast growth factor 20) is a neurotrophin which plays an important role in growth and survival of neurons. It is mainly required for the survival of dopaminergic cells. It plays an important role in central nervous development and function. FGF20 interacts with the tyrosine kinase FGF receptor-1 (FGFR1). Mutation in FGF20 (rs12720208) is associated with the susceptibility of Parkinson′s disease. It is also a putative proto-oncogene. It is required for maintaining the Wnt/β-catenin pathway-mediated anchorage-independent cellular growth.

Physical form

Lyophilized from 20 mM Tris, pH 7.6, containing 1.5 M NaCl.

Reconstitution

Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

WGK Germany

3

Certificado de Análisis
Genetic variation in FGF20 modulates hippocampal biology.
Lemaitre H, et al.
The Journal of Neuroscience, 30, 5992-5992 (2010)
Gene-gene interaction between FGF20 and MAOB in Parkinson disease.
Gao X, et al.
Annals of Human Genetics, 72, 157-157 (2008)
Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease.
van der Walt JM, et al.
American Journal of Human Genetics, 74, 1121-1121 (2004)
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.
Wang G, et al.
American Journal of Human Genetics, 82, 283-283 (2008)
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
Chamorro MN, et al.
The Embo Journal, 24, 73-73 (2005)
Artículos
Fibroblast growth factors in cell culture and various growth factors for your research
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