Myostatin Proform human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

MSTN Muscle Hypertrophy, Growth Differentiation Factor 8, GDF-8, MSTN
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source



expressed in E. coli


≥98% (HPLC)
≥98% (SDS-PAGE)



mol wt

~27.8 kDa


pkg of 10 μg


endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... MSTN(2660)

General description

MSTN (myostatin) belongs to the transforming growth factor-β (TGF β) superfamily containing numerable homologous cytokine proteins. This gene is expressed in skeletal muscle, and codes for a precursor protein composed of an N-terminal leader peptide, a pro-peptide domain, and a C-terminal domain. This precursor protein is proteolytically cleaved by bone morphogenetic protein 1 (BMP-1) at a conserved four amino acid RSRR site to produce the 13kDa mature protein.

Biochem/physiol Actions

MSTN (myostatin) functions as a negative modulator of muscle cell development. It functions through forming heteromeric receptor complexes such as with activin type II receptor B (ActRIIB), and with lesser affinity with ActIIA. This interaction results in the recruitment of type I receptors like activin receptor-like kinase 4 (ALK4) or ALK5, leading to the phosphorylation of Smad2 (small mothers against decapentaplegic) and Smad3, which move to the nucleus and suppress myogenesis. In MSTN-null mice, there is delayed skin wound healing due to the increased expression of decorin, an endogenous transforming growth factor-β (TGF β) suppressor. Topical treatment with TGF-β1 restored skin wound healing, suggesting that MSTN agonists might have therapeutic beneficial in skin wound repair.

Physical form

Lyophilized without any additives.


Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.


NONH for all modes of transport

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-? signaling by decorin.
Zhang C
American Journal of Physiology. Cell Physiology, 302, 1213-1225 (2012)
Myostatin rapid sequence evolution in ruminants predates domestication.
Tellgren A
Molecular Phylogenetics and Evolution, 33, 782-790 (2004)
Qiqi Yang et al.
Disease models & mechanisms, 12(2) (2019-02-06)
Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic krasG12V , we observed a progressive muscle-wasting phenotype in adult...

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