SRP4914

Sigma-Aldrich

Nesfatin-1 from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinónimos:
Nesfatin 1
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

rat

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

~8.0 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... Nucb3(59295)

General description

Nesfatin-1, a bioactive polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein, expressed in the appetite-control hypothalamic nuclei. It is also expressed in peripheral tissues. Nesfatin is involved in the regulation of the feeding behavior. Intracerebroventicular injection of nesfatin-1 reduces body weight in rats by affecting the animal food intake. Nesfatin-1 modulates energy balance by the reduction of food intake. It also has roles in gastrointestinal motility, control of blood pressure and stress and in glucose homeostasis.

Application

Nesfatin-1 from rat has been used to study its modulatory effects on gastric vagal afferent signals in mice.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with sterile water to a concentration of 0.1-1 mg/mL. Further dilutions should be made with medium containing 0.2% BSA.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Nesfatin-1 modulates murine gastric vagal afferent mechanosensitivity in a nutritional state dependent manner
Stephen J
Peptides, 89 (2017)
Peripheral and central localization of the nesfatin-1 receptor using autoradiography in rats.
Biochemical and Biophysical Research Communications (2016)
The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system.
Dore R
The Journal of Endocrinology (2017)

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