All Photos(1)



IL-28 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE), ≥85% (HPLC)

IFN-λ 2, Interleukin-28A, IL28A, Cytokine ZCYTO20, Interferon-λ 2
Número MDL:

origen biológico



expressed in E. coli


≥85% (HPLC)
≥85% (SDS-PAGE)



mol peso

~19.6 kDa


pkg of 20 μg


endotoxin, tested

Nº de acceso NCBI

enviado en

wet ice

temp. de almacenamiento


Gene Information

human ... IL28(282616)

Descripción general

IL-28 (interleukin 28), or IFNL2 (interferon λ2), belongs to the novel IFN type III family, which contains IL-29 and IL-28A and IL-28B. IL-28A and IL-28B share >95% sequence identity. This gene is localized to human chromosome 19.
Recombinant human IL-28A produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 19.6kDa.

Acciones bioquímicas o fisiológicas

IL-28A (interleukin 28) can inhibit multiple types of virus, and is also capable of preventing HSV-1 (herpes simplex virus type 1) infection of human neuronal cells. The antiviral property of IL-28A is attributable to IL-28A being capable of activating the expression of various Toll-like receptors (TLRs) and stimulating the TLR-mediated antiviral pathway, such as IFN regulatory factor 7, IFN-α, and the central IFN-α stimulated antiviral genes. IL-28A also acts as an inhibitory factor in HCV (hepatitis C virus) replication, and its expression is increased in HCV patients. This HCV antiviral activity is the result of IL-28A activating JAK-STAT (Janus kinase-signal transducer and activator of transcription) signaling pathway and the activation of certain interferon-stimulated genes (ISGs), such as 6-16 and 1-8U. Therefore, it might have potential as a therapeutic target in the treatment of HCV.

Forma física

Lyophilized without additives.


Reconstitute in sterile dH2O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service