SRP5039

Sigma-Aldrich

ICK, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:
LCK2, MGC46090, MRK, KIAA0936, ECO
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

4.1-5.5 nmol/min·mg

mol wt

~98 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ICK(22858)

General description

ICK or intestinal cell kinase belongs to a very extensive family of proteins that share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. ICK encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. ICK localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. ICK purified from transfected human embryonic kidney cells undergoes autophosphorylation and phosphorylates a test protein. ICK plays a key role in development of central nervous, skeletal, and endocrine systems.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point F

Not applicable

Flash Point C

Not applicable

Piya Lahiry et al.
American journal of human genetics, 84(2), 134-147 (2009-02-03)
Six infants in an Old Order Amish pedigree were observed to be affected with endocrine-cerebro-osteodysplasia (ECO). ECO is a previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. Autozygosity mapping and sequencing identified...
K Togawa et al.
Journal of cellular physiology, 183(1), 129-139 (2000-03-04)
Identification of key regulatory kinases in the intestinal epithelium are useful to understand the molecular mechanisms that underlie proliferation and differentiation in cells found in this compartment. We used the polymerase chain reaction (PCR) to amplify the catalytic kinase domain...

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