SRP5111

Sigma-Aldrich

p33ING1, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:
ING1, p24ING1c, p47ING1a, p33, p33ING1b, p47
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~38 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ING1(3621)

General description

p33ING1 displays characteristics of a tumour suppressor protein and can induce cell growth arrest and apoptosis. p33ING1 is a nuclear protein and acute expression of p33 ING1 inhibits cell growth. p33ING1 physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Mutation of p33ING1 gene occurs in neuroblastoma cells and reduced expression is observed in some breast cancer cell lines. It has been proposed that p33ING1 can act as a potent growth regulator in normal and in established cells and plays a role as a candidate tumour suppressor gene whose inactivation may contribute to the development of cancers.

Physical form

Supplied in 50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

pictograms

Exclamation markHealth hazard

signalword

Danger

Hazard Codes

T

Risk Statement

61

Safety Statement

53-45

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point F

Not applicable

Flash Point C

Not applicable

Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
Garkavtsev
Nature genetics, 23(3), 373-373 (1999-11-05)
Frauke Goeman et al.
Molecular and cellular biology, 25(1), 422-431 (2004-12-17)
ING1 was identified as an inhibitor of growth and has been described as a tumor suppressor. Furthermore, the expression of ING1 is induced in senescent cells and antisense ING1 extends the proliferative life span of primary human fibroblasts. Cooperation of...

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