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SRP5119

Sigma-Aldrich

PRKAR1A, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):
TSE1, PPNAD1, PRKAR1, CNC, PKR1, CAR, DKFZp779L0468, MGC17251, CNC1
CAS Number:
NACRES:
NA.32

origen biológico

human

recombinante

expressed in baculovirus infected Sf9 cells

ensayo

≥70% (SDS-PAGE)

formulario

buffered aqueous glycerol solution

mol peso

~51 kDa

Nº de acceso NCBI

application(s)

cell analysis

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... PRKAR1A(5573)

Descripción general

PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).

Forma física

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Nota de preparación

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

pictogramas

Exclamation markHealth hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Certificate of Analysis

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Certificate of Origin

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