SRP5137

Sigma-Aldrich

STAT1 β, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:
DKFZp686B04100, ISGF-3, STAT91
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~118 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... STAT1(6772)

General description

STAT1β is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT1β transcription factor is specific for the IFN pathway and plays a central role in mediating many, if not all, IFN-dependent biological responses. Presence of STAT1β leads to an efficient antiviral response when cells were infected with virus suggesting that a STAT-dependent pathway is activated following virus infection by endogenously produced IFN. Virus-induced STAT protein translocation from the cytoplasmic compartment can be detected within 3 h of infection.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

T Improta et al.
Cytokine, 9(6), 383-393 (1997-06-01)
Interferon (IFN) signalling appears to be the predominant pathway that leads to the development of the host defence against virus. However, other mechanisms that are IFN independent may also be involved. The Stat1 transcription factor is specific for the IFN...

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