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  • SRP5222
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SRP5222

Sigma-Aldrich

MSK2, active, GST tagged from mouse

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

All Photos(2)
Synonym(s):
RPS6KA4, RSK-B, RSKB
NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

Línea del producto

PRECISIO® Kinase

ensayo

≥70% (SDS-PAGE)

formulario

buffered aqueous glycerol solution

specific activity

7.5-10.4 nmol/min·mg

mol peso

~114 kDa

Nº de acceso NCBI

BC012964

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

mouse ... Rps6ka4(56613)

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NEK1, active, GST tagged from mouse

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

specific activity

7.5-10.4 nmol/min·mg

specific activity

190-256 nmol/min·mg

specific activity

315-426 nmol/min·mg

specific activity

56-84 nmol/min·mg

mol wt

~114 kDa

mol wt

~64 kDa

mol wt

~88 kDa

mol wt

~85 kDa

NCBI accession no.

BC012964

NCBI accession no.

-

NCBI accession no.

NM_080788

NCBI accession no.

NM_175089

Descripción general

MSK2 (mitogen- and stress-activated protein kinase-2) is a member of the serine/threonine kinase family that contains two non-identical kinase catalytic domains. MSK2 is also known as ribosomal protein S6 kinase polypeptide 4 (RPS6KA4), that is activated by the mitogen-activated protein kinases- extracellular signal-regulated kinases 1 and 2 (ERK1 and -2) and p38.

Acciones bioquímicas o fisiológicas

MSK2 (mitogen- and stress-activated protein kinase-2) phosphorylates various substrates like cyclic AMP-responsive element-binding protein 1 (CREB1) and the proto-oncogene c-fos. It is a histone-modifying enzyme and a mitogenic factor. The protein is involved in the G1-phase of the cell cycle and has a role in apoptosis. It also modulates the functions of various transcription factors.

Forma física

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Nota de preparación

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Información legal

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 1

Certificate of Analysis

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Certificate of Origin

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