SRP5228

Sigma-Aldrich

PIM3 active, GST tagged from mouse

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:
Kid1, MGC27707, MGC37517
En este momento no podemos mostrarle ni los precios ni la disponibilidad

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

667-903 nmol/min·mg

mol wt

~63 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Pim3(223775)

General description

PIM3 or pim-3 oncogene belongs to a family of protooncogenes that encode serine/threonine protein kinases. Pim-3 expressed in hepatocellular carcinoma development and plays a main role in the proliferation of human hepatoma cell lines. Pim-3 also expressed in human pancreatic cancer cell and phosphorylates BAD to block Bad-mediated apoptosis in human pancreatic cancer cell lines.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Harald Mikkers et al.
Molecular and cellular biology, 24(13), 6104-6115 (2004-06-17)
The Pim family of proto-oncogenes encodes a distinct class of serine/threonine kinases consisting of PIM1, PIM2, and PIM3. Although the Pim genes are evolutionarily highly conserved, the contribution of PIM proteins to mammalian development is unclear. PIM1-deficient mice were previously...
Ying-Yi Li et al.
Cancer research, 66(13), 6741-6747 (2006-07-05)
Pancreatic cancer still remains a serious health problem with <5% 5-year survival rate for all stages. To develop an effective treatment, it is necessary to identify a target molecule that is crucially involved in pancreatic tumor growth. We previously observed...
Chifumi Fujii et al.
International journal of cancer, 114(2), 209-218 (2004-11-13)
Most cases of human hepatocellular carcinoma develop after persistent chronic infection with human hepatitis B virus or hepatitis C virus, and host responses are presumed to have major roles in this process. To recapitulate this process, we have developed the...

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