IL-19 from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

MDA1, IL-10C, ZMDA1, Melanoma differentiation association like protein, NG.1
Número de CAS:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source



expressed in E. coli


≥95% (HPLC)
≥95% (SDS-PAGE)



mol wt

17.7 kDa


pkg of 10 μg


Endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.


Gene Information

mouse ... IL19(329244)

Categorías relacionadas

General description

IL19 (interleukin 19) belongs to the IL-10 family of cytokines, and shares high homology with IL-20 and IL-24 at the primary level. It is further subcategorized into a subfamily containing IL-19, IL-20, and IL-24. It was first discovered in 2001, and its expression is not only limited to leukocytes and is also expressed by angiogenic tissue.

Biochem/physiol Actions

IL19 (interleukin 19) promotes the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, and therefore, participates in the pathogenesis of autoimmune diseases such as psoriasis, asthma, and rheumatoid arthritis. This protein functions as a strong pro-angiogenic influence on different human EC (endothelial cell) types, such as umbilical vein, coronary artery, and microvascular types. In Th2 (T helper)-mediated colitis rat model IL-19 functions as an anti-inflammatory agent, and might have potential as a therapeutic target for alleviating colonic inflammation.

Physical form

Sterile filtered and lyophilized with no additives


Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-0.5 mg/ml. The solution can be diluted into other aqueous buffers


NONH for all modes of transport

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
IL-19 reduces ligation-mediated neointimal hyperplasia by reducing vascular smooth muscle cell activation.
Ellison S et al
The American Journal of Pathology, 184(7), 2134-2143 (2014)
Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis.
Fujimoto Y et al
Naunyn-Schmiedeberg'S Archives of Pharmacology, 390(3), 261-268 (2017)
Michelle L Manni et al.
Journal of immunology (Baltimore, Md. : 1950), 196(3), 963-977 (2016-01-06)
IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an influential role in asthma pathogenesis. We examined the role of IL-13 and IL-17A in mediating airway hyperresponsiveness (AHR), lung inflammation, and mucus metaplasia in a dual Th2/Th17...
Carol Hoffman et al.
PloS one, 6(11), e27629-e27629 (2011-11-24)
Interleukin (IL)-19 has been reported to enhance chronic inflammatory diseases such as asthma but the in vivo mechanism is incompletely understood. Because IL-19 is produced by and regulates cells of the monocyte lineage, our studies focused on in vivo responses...
James Richards et al.
Journal of molecular and cellular cardiology, 79, 21-31 (2014-12-03)
Hypoxia in ischemic limbs typically initiates angiogenic and inflammatory factors to promote angiogenesis in attempt to restore perfusion. There is a gap in our knowledge concerning the role of anti-inflammatory interleukins in angiogenesis, macrophage polarization, and endothelial cell activation. Interleukin-19...

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