SRP6017

Sigma-Aldrich

IL-19 from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinónimos:
MDA1, IL-10C, ZMDA1, Melanoma differentiation association like protein, NG.1
Número de CAS:
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

mouse

recombinant

expressed in E. coli

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

17.7 kDa

packaging

pkg of 10 μg

impurities

Endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... IL19(329244)

Categorías relacionadas

General description

IL19 (interleukin 19) belongs to the IL-10 family of cytokines, and shares high homology with IL-20 and IL-24 at the primary level. It is further subcategorized into a subfamily containing IL-19, IL-20, and IL-24. It was first discovered in 2001, and its expression is not only limited to leukocytes and is also expressed by angiogenic tissue.

Biochem/physiol Actions

IL19 (interleukin 19) promotes the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, and therefore, participates in the pathogenesis of autoimmune diseases such as psoriasis, asthma, and rheumatoid arthritis. This protein functions as a strong pro-angiogenic influence on different human EC (endothelial cell) types, such as umbilical vein, coronary artery, and microvascular types. In Th2 (T helper)-mediated colitis rat model IL-19 functions as an anti-inflammatory agent, and might have potential as a therapeutic target for alleviating colonic inflammation.

Physical form

Sterile filtered and lyophilized with no additives

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-0.5 mg/ml. The solution can be diluted into other aqueous buffers

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
IL-19 reduces ligation-mediated neointimal hyperplasia by reducing vascular smooth muscle cell activation.
Ellison S et al
The American Journal of Pathology, 184(7), 2134-2143 (2014)
Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis.
Fujimoto Y et al
Naunyn-Schmiedeberg'S Archives of Pharmacology, 390(3), 261-268 (2017)
Michelle L Manni et al.
Journal of immunology (Baltimore, Md. : 1950), 196(3), 963-977 (2016-01-06)
IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an influential role in asthma pathogenesis. We examined the role of IL-13 and IL-17A in mediating airway hyperresponsiveness (AHR), lung inflammation, and mucus metaplasia in a dual Th2/Th17...
Carol Hoffman et al.
PloS one, 6(11), e27629-e27629 (2011-11-24)
Interleukin (IL)-19 has been reported to enhance chronic inflammatory diseases such as asthma but the in vivo mechanism is incompletely understood. Because IL-19 is produced by and regulates cells of the monocyte lineage, our studies focused on in vivo responses...
James Richards et al.
Journal of molecular and cellular cardiology, 79, 21-31 (2014-12-03)
Hypoxia in ischemic limbs typically initiates angiogenic and inflammatory factors to promote angiogenesis in attempt to restore perfusion. There is a gap in our knowledge concerning the role of anti-inflammatory interleukins in angiogenesis, macrophage polarization, and endothelial cell activation. Interleukin-19...

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