Merck
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SRP6051

Sigma-Aldrich

RAGE human

recombinant, expressed in human cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):
NGF-2, HDNF, NT-3, Neurotrophin-3, Receptor for advanced glycosylation end products
CAS Number:
NACRES:
NA.32

origen biológico

human

recombinante

expressed in human cells

ensayo

≥95% (HPLC)
≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

~35 kDa

envase

pkg of 10 μg

Nº de acceso NCBI

enviado en

wet ice

temp. de almacenamiento

−20°C

Gene Information

human ... AGER(117)

Descripción general

Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

Forma física

Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.

Otras notas

Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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