SRP6113

Sigma-Aldrich

UGDH human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinónimos:
GDH, UDP-GlcDH, UDP-glucose dehydrogenase, UGD, UDPGDH
Número de CAS:
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

liquid

mol wt

59.5 kDa (533 aa, 1-494 aa + NT His-Tag)

packaging

pkg of 50 μg

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UGDH(7358)

General description

UDP-glucose 6-dehydrogenase (UGDH) is encoded by the gene mapped to human chromosome 4p14. UGDH is part of the UDP-glucose/GDP-mannose dehydrogenase family and is a widely expressed enzyme localized in the liver.

Biochem/physiol Actions

UDP-glucose 6-dehydrogenase (UGDH) transfers UDP-glucose to UDP-glucuronate and thus takes part in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. UGDH is implicated in various cellular processes such as, detoxification, polysaccharide biosynthesis and embryonic development.

Physical form

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1 mM DTT, 0.1 M NaCl, and 1 mM EDTA.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM FEIKKICCIG AGYVGGPTCS VIAHMCPEIR VTVVDVNESR INAWNSPTLP IYEPGLKEVV ESCRGKNLFF STNIDDAIKE ADLVFISVNT PTKTYGMGKG RAADLKYIEA CARRIVQNSN GYKIVTEKST VPVRAAESIR RIFDANTKPN LNLQVLSNPE FLAEGTAIKD LKNPDRVLIG GDETPEGQRA VQALCAVYEH WVPREKILTT NTWSSELSKL AANAFLAQRI SSINSISALC EATGADVEEV ATAIGMDQRI GNKFLKASVG FGGSCFQKDV LNLVYLCEAL NLPEVARYWQ QVIDMNDYQR RRFASRIIDS LFNTVTDKKI AILGFAFKKD TGDTRESSSI YISKYLMDEG AHLHIYDPKV PREQIVVDLS HPGVSEDDQV SRLVTISKDP YEACDGAHAV VICTEWDMFK ELDYERIHKK MLKPAFIFDG RRVLDGLHNE LQTIGFQIET IGKKVSSKRI PYAPSGEIPK FSLQDPPNKK PKV

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Ping Cai et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1090-1093 (2015-03-15)
An NADPH-dependent sorbose reductase from Candida albicans was identified to catalyze the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate (COBE). The activity of the recombinant enzyme toward COBE was 6.2 U/mg. The asymmetric reduction of COBE was performed with two coexisting recombinant...
Assignment1 of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15. 1 by radiation hybrid mapping.
Marcu O, et al.
Cytogenetic and genome research, 86(3-4), 244-245 (1999)
UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces.
Hyde A S, et al.
The Journal of Biological Chemistry, M113-M113 (2013)
cDNA cloning and expression analysis of the human UDPglucose dehydrogenase.
Peng H L, et al.
Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 22(4), 166-172 (1998)
Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer.
Tada M, et al.
Cancer Science, 101(5), 1261-1269 (2010)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico

Redes sociales

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Investigación. Desarrollo. Producción.

Somos un proveedor líder para la industria de Ciencias de la Vida con soluciones y servicios para investigación, desarrollo y producción biotecnológicos, y para desarrollo y producción de tratamientos farmacéuticos

© 2021 Merck KGaA, Darmstadt, Alemania y/o sus filiales. Todos los derechos reservados.

Queda estrictamente prohibida la reproducción sin permiso de cualquiera de los materiales de la página web.