SRP6120

Fumarase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Synonym(s): Fumarate hydratase, MCL, MCUL1, LRCC, FH
• CAS Number: 9032-88-6
• NACRES: NA.32

Properties

• origen biológico: human
• recombinante: expressed in E. coli
• ensayo: ≥95% (SDS-PAGE)
• formulario: liquid
• potencia: >1.0 units/mg
• mol peso: 50.2 kDa (467 aa, 44-510 aa)
• envase: pkg of 100 μg
• impurezas: <1.0 EU/μg
• Nº de acceso NCBI: P07954
• Nº de acceso UniProt: P07954
• enviado en: dry ice
• temp. de almacenamiento: −70°C
• Gene Information: human ... FH(2271)

Description

Descripción general

Fumarase (Fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor.

Forma física

1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0).

Nota de preparación

Centrifuge the vial prior to opening.

Otras notas

MASQNSFRIE YDTFGELKVP NDKYYGAQTV RSTMNFKIGG VTERMPTPVI KAFGILKRAA AEVNQDYGLD PKIANAIMKA ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKI PVHPNDHVNK SQSSNDTFPT AMHIAAAIEV HEVLLPGLQK LHDALDAKSK EFAQIIKIGR THTQDAVPLT LGQEFSGYVQ QVKYAMTRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK ETAIELGYLT AEQFDEWVKP KDMLGPK

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable