SRP6120

Fumarase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Sinónimos: Fumarate hydratase, MCL, MCUL1, LRCC, FH
• Número de CAS: 9032-88-6
• NACRES: NA.32

Propiedades

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥95% (SDS-PAGE)
• form: liquid
• potency: >1.0 units/mg
• mol wt: 50.2 kDa (467 aa, 44-510 aa)
• packaging: pkg of 100 μg
• impurities: <1.0 EU/μg
• NCBI accession no.: P07954
• UniProt accession no.: P07954
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FH(2271)

Descripción

General description

Fumarase (Fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor.

Physical form

1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0).

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MASQNSFRIE YDTFGELKVP NDKYYGAQTV RSTMNFKIGG VTERMPTPVI KAFGILKRAA AEVNQDYGLD PKIANAIMKA ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKI PVHPNDHVNK SQSSNDTFPT AMHIAAAIEV HEVLLPGLQK LHDALDAKSK EFAQIIKIGR THTQDAVPLT LGQEFSGYVQ QVKYAMTRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK ETAIELGYLT AEQFDEWVKP KDMLGPK

Información de seguridad

• RIDADR: NONH for all modes of transport
• WGK Germany: WGK 3
• Flash Point F: Not applicable
• Flash Point C: Not applicable