Merck
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SRP6136

Sigma-Aldrich

Ubiquitin-K29R human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥95% (SDS-PAGE)

formulario

liquid

mol peso

8.592 kDa

envase

pkg of 500 μg

Nº de acceso NCBI

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... RPS27A(6233)

Descripción general

Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one of the seven lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have a single substitution of arginine for lysine at position 29. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach. Ubiquitin plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.

Forma física

4 mg/mL in 20 mM Tris, pH 7.5, 0.15 M NaCl and 10% glycerol.

Nota de preparación

Centrifuge the vial prior to opening.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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