Merck
All Photos(2)

SRP6155

Sigma-Aldrich

BMP-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(s):
BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A
NACRES:
NA.32

origen biológico

human

recombinante

expressed in HEK 293 cells

ensayo

≥95% (SDS-PAGE)

formulario

lyophilized

potencia

20-100 ng/mL ED50

mol peso

30-38 kDa (homodimer, glycosylated)

envase

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

Nº de acceso NCBI

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... BMP2(650)

Descripción general

BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

Aplicación

BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.

Acciones bioquímicas o fisiológicas

BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.

Forma física

Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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