Merck
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SRP6178

Sigma-Aldrich

TACE, human

recombinant, expressed in insect cells, ≥90% (SDS-PAGE)

Synonym(s):
Snake venom-like protease, Disintegrin and metalloproteinase domain-containing protein 17, CD156b, TNF-alpha convertase, ADAM17
NACRES:
NA.32

origen biológico

human

recombinante

expressed in insect cells

ensayo

≥90% (SDS-PAGE)

formulario

lyophilized powder

mol peso

62 kDa

envase

pkg of 20 μg

Nº de acceso NCBI

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... ADAM17(6868)

Descripción general

A disintegrin and metallopeptidase domain 17 (ADAM17) belongs to ADAM family of genes, which has a characteristic cysteine rich region called disintegrin and a metalloproteinase domain. This gene is located on chromosome 2, spans 55kb and has 19 exons. In adult humans, ADAM17 is expressed in multiple tissues such as, heart, muscle, kidney, placenta, pancreas, thymus, small intestine, ovaries, testes and prostate. In fetus, it is expressed in brain, lung, liver and kidney.

Acciones bioquímicas o fisiológicas

ADAMs (A disintegrin and metallopeptidases) are called ectodomain sheddases and ADAM17 is an angiotensin-converting enzyme 2 (ACE2) sheddase. It also processes and sheds multiple cell surface molecules such as, adhesion molecules and cytokines. It produces the soluble form of tumor necrosis factor α (TNF-α), along with the processing of I-CAM (cell adhesion molecule), V-CAM, IL-6R, L-selectin etc. These in turn play a role in development, regeneration and inflammation of the circulatory system. Polymorphism rs12692386 in ADAM17 gene is associated with an increased susceptibility to abdominal aortic aneurysm. This gene is also up-regulated in myocardial infarction patients, as well as in atherosclerosis patients. It also plays a role in the pathophysiology of ischemic strokes (IS). ADAM17 aids in tumor progression by facilitating tumor proliferation and invasion, as in the case of non-small cell lung cancer (NSCLC).

Forma física

The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

With sterile deionized water at 0.1 μg protein/μL.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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