SRP6182

Sigma-Aldrich

Human Serum Albumin

≥98% (SDS-PAGE)

Sinónimos:
PRO2044, GIG20, GIG42, PRO1708, HSA, UNQ696/PRO1341, PRO2619, PRO2675, serum albumin, PRO0903
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

assay

≥98% (SDS-PAGE)

form

liquid

mol wt

66.4 kDa

packaging

pkg of 1 mg

concentration

250 mg/mL

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... ALBU(213)

General description

The gene HSA (human serum albumin) is mapped to human chromosome 4q13.3. The gene encodes a protein of 585 amino acids with a molecular weight of 66.4kDa. HSA is the most abundant protein in the plasma and has many metal-binding sites.

Application

HSA (human serum albumin) has been used for the development of automated dye-binding method for serum albumin determination using bromcresol purple. It has also been used to study effect of HSA on DNA transfection by lipoplexes.

Biochem/physiol Actions

HSA (human serum albumin) mainly works as a carrier for various nutrients, metabolites and xenobiotics. It interacts with plasma zinc and regulates uptake of zinc in cells. HSA plays a crucial role in drug pharmacokinetics. It also controls oncotic pressure and volume of the blood. Mutations in the gene are linked with congenital analbuminemia and familial dysalbuminemic hyperthyroxinemia.

Physical form

Sterile filtered yellowish liquid.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum.
Sim?es S
Biochimica et Biophysica Acta, 1463, 459-469 (2000)
Structure and ligand binding properties of human serum albumin.
Kragh-Hansen U
Danish Medical Bulletin, 37, 57-84 (1990)
Structural basis of non-steroidal anti-inflammatory drug diclofenac binding to human serum albumin.
Zhang Y
Chemical Biology & Drug Design, 86, 1178-1184 (2015)
New automated dye-binding method for serum albumin determination with bromcresol purple.
Pinnell AE and Northam BE
Clinical Chemistry, 24, 80-86 (1978)
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families.
Sunthornthepvarakul T
Biochemical and Biophysical Research Communications, 202, 781-787 (1994)

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