Merck
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SRP6280

Sigma-Aldrich

BRD3(306-417) his tag

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):
KIAA0043, RING3L
NACRES:
NA.32

recombinante

expressed in E. coli

ensayo

≥98% (SDS-PAGE)

formulario

liquid

mol peso

15.5 kDa

envase

pkg of 1 mg
pkg of 100 μg
pkg of 20 μg

concentración

2 mg/mL

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... BRD3(8019)

Descripción general

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. The recombinant protein includes Bromodomain-containing protein 3 (contains 306-417 aa) with N-terminal His-tag.

Forma física

rh-BRD3-BD2 is supplied as a solution in PBS Buffer containing 10% glycerol.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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