SRP6303

Sigma-Aldrich

Apolipoprotein E from human plasma

≥95% (SDS-PAGE)

Sinónimos:
ApoE
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human plasma

assay

≥95% (SDS-PAGE)

form

frozen liquid

mol wt

34 kDa

packaging

pkg of 50 μg

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ApoE(348)

General description

Apolipoprotein E (ApoE) is an important constituent of all plasma lipoproteins. The concentration of Apo E in normal plasma is 5 mg/100mL. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. It exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. The gene encoding this protein is localized on human chromosome 19q13.32.

Biochem/physiol Actions

Apolipoprotein E (ApoE) serves as a ligand for low density receptors and participates in the transport and redistribution of cholesterol and other lipids. Other functions include immunoregulation, cell growth modulation and differentiation. Apo E is thought to be involved in tissue repair as increased amounts of the protein are found at sites of peripheral nerve injury and regeneration. A mutant form is associated with familial type III hyperlipoproteinemia. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. ApoE′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the low-density lipoprotein (LDL) receptor (apo B/E).

Physical form

Frozen in 50 mM NH4HCO3, pH 8.0.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J
Aging Cell, 10(4), 686-698 (2011)
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Mahley RW
Journal of Lipid Research, 40(11), 1933-1949 (1999)
Karol Kaiser et al.
Nature communications, 10(1), 1498-1498 (2019-04-04)
WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced...
Apolipoprotein E isoforms and lipoprotein metabolism.
Phillips MC
IUBMB Life, 66(9), 616-623 (2014)
Apolipoprotein E-low density lipoprotein receptor binding: study of protein-protein interaction in rationally selected docked complexes.
Prevost M and Raussens V
Proteins: Structure, Function, and Genetics, 55(4), 874-884 (2004)

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