Merck
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SRP6309

Sigma-Aldrich

Proteinase 3 from human neutrophils

≥95% (SDS-PAGE)

Synonym(s):
Leukocyte proteinase 3, Neutrophil proteinase 4, P29, C-ANCA antigen, AGP7, Wegener autoantigen

origen biológico

human

ensayo

≥95% (SDS-PAGE)

formulario

frozen liquid

mol peso

29 kDa

envase

pkg of 25 μg

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... AGP7(5657)

Related Categories

Descripción general

Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by α1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation. Proteinase 3 (PR-3) is also known as myeloblastin and p29b.

Forma física

Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

nwg

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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