SRP6339

Sigma-Aldrich

IRF3 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinónimos:
Interferon regulatory factor-3
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

liquid

mol wt

13 kDa (112 aa, 1-112 aa)

packaging

pkg of 50 μg

concentration

1 mg/mL

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... IRF3(3661)

General description

Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. Recombinant human IRF3 was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

1 mg/mL in Phosphate-buffered saline (pH 7.4).

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Mingjin Yang et al.
The Journal of experimental medicine, 208(10), 2099-2112 (2011-09-14)
The carboxyl terminus of constitutive heat shock cognate 70 (HSC70)-interacting protein (CHIP, also known as Stub1) is a U box-containing E3 ubiquitin ligase that is important for protein quality control. The role of CHIP in innate immunity is not known....
Fabrizio C Lucchini et al.
Nature communications, 11(1), 1642-1642 (2020-04-04)
Increasing energy expenditure via induction of adipose tissue browning has become an appealing strategy to treat obesity and associated metabolic complications. Herein, we identify adipocyte-expressed apoptosis signal-regulating kinase 1 (ASK1) as regulator of adipose tissue browning. High fat diet-fed adipocyte-specific...

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