Merck
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SRP6348

Sigma-Aldrich

ULBP2 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Synonym(s):
N2DL2, NKG2D ligand 2, RAET1H
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥85% (SDS-PAGE)

formulario

liquid

mol peso

24.3 kDa (216 aa, 26-216 aa + His Tag)

envase

pkg of 100 μg

concentración

1 mg/mL

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... ULBP2(80328)

Descripción general

ULBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Forma física

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 30% glycerol, 2 M Urea and 2 mM DTT.

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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