SRP6358

Sigma-Aldrich

CXCL4 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Sinónimos:
Chemokine (C-X-C motif) ligand 4, SCYB4, MGC138298, PF4
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in E. coli

assay

≥85% (SDS-PAGE)

form

liquid

mol wt

10 kDa (91 aa, 32-101 aa + His Tag)

packaging

pkg of 20 μg

concentration

0.25 mg/mL

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CXCL4(5196)

Categorías relacionadas

General description

Platelet factor-4 (PF-4) or chemokine (C-X-C motif) ligand 4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. Recombinant human CXCL4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Biochem/physiol Actions

Platelet factor-4 (PF-4) or chemokine (C-X-C motif) ligand 4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. This protein associates with heparin and neutralizes it. It also neutralizes various negatively charged proteoglycans.

Physical form

0.25 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 2 mM DTT and 50% glycerol.

pictograms

Exclamation mark

signalword

Warning

hcodes

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Tiago Carvalheiro et al.
Frontiers in immunology, 11, 1793-1793 (2020-09-26)
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands....
Kai Huang et al.
Annals of palliative medicine, 9(5), 2723-2730 (2020-09-22)
Chronic osteomyelitis is associated with the immune suppression. CD4(+)CD25(+) FOXP3(+) regulatory T cells (Tregs) play a key role in the peripheral tolerance to prevent immune responses to self-antigens and allergens. Evidence has suggested that the accumulation and activity of Tregs...
CXCL4 Plasma Levels Are Not Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology.
Erbel C
PLoS ONE, 10(11), e0141693-e0141693 (2015)
Transformation-associated cytokine 9E3/CEF4 is chemotactic for chicken peripheral blood mononuclear cells.
Barker KA
Journal of Virology, 67(6), 3528-3533 (1993)

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