SRP6376

Sigma-Aldrich

CD273 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinónimos:
PDCD1LG2, Butyrophilin B7-DC, PDL2, PDCD1 ligand 2, PDCD1L2
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

calculated mol wt 23.4 kDa
observed mol wt 35-48 kDa (DTT-reduced. Protein migrates due to glycosylation. Leu 20 is the predicted N-terminus.)

packaging

pkg of 10 μg
pkg of 50 μg

conjugate

6-His tagged (C-terminus)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PDCD1LG2(80380)

General description

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as butyrophilin B7-DC or CD antigen CD273. It belongs to the immunoglobulin superfamily or BTN/MOG family. The gene encoding CD273 is localized on human chromosome 9p24.1.

Biochem/physiol Actions

The expression of programmed cell death 1 ligand 2 (PD-L2) or CD antigen 273 (CD273) is up-regulated by interferon-γ (IFNG/IFN-γ) stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with colony-stimulating factor-2 (CSF2) and interleukin-4 (IL-4). PD-L2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
PD-L2:PD-1 involvement in T cell proliferation,
cytokine production, and integrin-mediated adhesion
Paul. A. Saunders
European Journal of Immunology, 35 (2005)
No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation
Katrina P
European Journal of Immunology, 36(5), 1104-1113 (2006)
Expression of Programmed Cell Death 1 Ligand 2 (PD-L2) is a Distinguishing Feature of Primary Mediastinal (Thymic) Large B-cell Lymphoma and Associated with PDCD1LG2 Copy Gain
Min Shi
American Journal of Surgical Pathology, 38(12), 1715-1723 (2014)

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