Merck
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SRP6418

Sigma-Aldrich

VTCN1 human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym(s):
B7-H4, B7S1, B7h.5
NACRES:
NA.32

origen biológico

human

recombinante

expressed in HEK 293 cells

etiqueta

6-His tagged (C-terminus)

ensayo

≥90% (SDS-PAGE)

formulario

lyophilized

mol peso

calculated mol wt 26.1 kDa
observed mol wt 45-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 29 is the predicted N-terminal.)

envase

pkg of 10 μg
pkg of 50 μg

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

−20°C

Gene Information

human ... VTCN1(79679)

Descripción general

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Forma física

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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