SRP6478

Sigma-Aldrich

FCER1A/FCE1A human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Sinónimos:
Ferris
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

calculated mol wt 21.9 kDa
observed mol wt 40-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Val 26 is the predicted N-terminal.)

packaging

pkg of 10 and 50 μg

conjugate

6-His tagged (C-terminus)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FCER1A(2205)

General description

FCER1A (Fc fragment of IgE receptor Ia) is from immunoglobulin (Ig) superfamily. It interacts with IgE Fc domain. The gene is mapped to human chromosome 1q23.

Biochem/physiol Actions

FCER1A (Fc fragment of IgE receptor Ia) is the α subunit of FcεRI (a heterotetramer (αβγ2)). FcεRI is a high-affinity IgE (immunoglobulin E) receptor. The IgE/FcεRI complex, along with antigens, results in transmission of inflammatory signal. These events cause degranulation of mast cells and basophils, and antigen presentation and cytokine generation in dendritic cells and monocytes. FcεRI plays an important role in allergic diseases via mast cell receptor associated immunological processes. Mutations in the FCER1A gene are associated with IgE-mediated allergic inflammation by Dermatophagoides pteronyssinus.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
An Exploratory Pilot Study of Genetic Marker for IgE-Mediated Allergic Diseases with Expressions of FceR1a and Ce.
Liao EC, et al.
International Journal of Molecular Sciences, 16, 9504-9504 (2015)
Tetraspanin CD151 Is a Negative Regulator of FceRI-Mediated Mast Cell Activation.
Abdala-Valencia H, et al.
Journal of Immunology, 195, 1377-1377 (2015)
Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model.
Baravalle G, et al.
Journal of Immunology, 192, 3280-3280 (2014)
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.
Weidinger S, et al.
PLoS Genetics, 4, e1000166-e1000166 (2008)
A role of FCER1A and FCER2 polymorphisms in IgE regulation.
Sharma V, et al.
Allergy, 69, 231-231 (2014)

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