Merck
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SRP6523

Sigma-Aldrich

ApoJ/Clusterin from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):
SGP2, TRPM2, SGP-2, Apolipoprotein J, TRPM-2, CLI, KUB1, AAG4, MGC24903, CLU
NACRES:
NA.32

origen biológico

mouse

recombinante

expressed in E. coli

ensayo

≥90% (SDS-PAGE)

formulario

liquid

mol peso

~45 kDa (Mouse nuclear Clusterin aa 22- 448 is fused at the C-terminus to a His-tag.)

envase

pkg of 10 μg
pkg of 50 μg

concentración

1 mg/mL

impurezas

<1 EU/μg endotoxin (LAL test)

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

−20°C

Gene Information

mouse ... CLU(12759)

Descripción general

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

Forma física

1 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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