SRP6532

Sigma-Aldrich

RBP4 human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Sinónimos:
Retinol Binding Protein 4, RBP, PRBP, Plasma retinol-binding protein
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥90% (SDS-PAGE)

form

liquid

mol wt

monomer ~230 kDa (Human RBP4 aa 19-201 is fused at the N-terminus to a FLAG0174-tag.)

packaging

pkg of 10 μg
pkg of 50 μg

impurities

<0.1 EU/μg endotoxin (LAL test)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... RBP4(5950)

General description

Retinol binding protein 4 (RBP4) is a 21kDa secreted protein encoded by the gene mapped to human chromosome 10q23–q24. RBP4 belongs to the lipocalin family, involved in the migration of small hydrophobic molecules. RBP4 is majorly expressed in liver and adipose tissues.

Biochem/physiol Actions

Retinol binding protein 4 (RBP4) acts as a primary transporter of retinol (vitamin A) in blood. RBP4 might act as a potent biomarker for abdominal obesity. Aberration in the expression of RBP4 is associated with the pathogenesis of Type 2 diabetes mellitus (T2DM), obesity and insulin resistance. Overexpression of serum RBP4 increases the risk for carotid artery plaque formation and coronary heart disease (CHD) in Chinese population. Therefore, regulation of serum RBP4 level might be implicated in prevention, diagnosis, and CHD treatment. A recent study in non-obese subjects revealed that decreased expression of glucose transporter 4 (GLUT4) in adipose tissues results in an elevated serum RBP4 level and insulin resistance.

Physical form

0.5 mg/mL of 0.2 μm-filtered solution in PBS, pH 7.2.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Serum Retinol-Binding Protein-4 Level is a High Risk Factor for Coronary Heart Disease in Chinese.
Dong H
Clinical Laboratory, 61(11), 1675-1678 (2015)
Serum retinol binding protein 4 is associated with visceral fat in human with nonalcoholic fatty liver disease without known diabetes: a cross-sectional study.
Chang X
Lipids in Health and Disease, 14:28 (2015)
Evaluation of the association between retinal binding protein 4 polymorphisms and type 2 diabetes in Chinese by DHPLC.
Liu J
Endocrine, 34(1-3), 23-28 (2008)
Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.
Hu S
BMC Pregnancy and Childbirth, 16:52 (2016)

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